Esperance used their home advantage and beat Mamelodi Sundowns 1-0 in the first leg of the CAF Champions League semi-final at Stade Olympique in Tunis, Tunisia, on Saturday evening.
Yan Sasse beat an offside trap and scored the only goal of the match four minutes before half-time.
The Brazilians and the Tunisians are going to meet again in the second leg, which is set for Pretoria next weekend.