The Springboks won their first match at Twickenham since 2014 when they beat England 27-13 in a Test match on Saturday evening.
The Boks scored two tries through Kurt-Lee Arendse and Eben Etzebeth while their opponents only had one try, which was scored by Henry Slade.
Faf de Klerk converted twice and also succeeded with three penalties with Damian Willemse adding two drop goals.
On the other hand, England flyhalf Owen Farrell succeeded with one conversion and two penalties.
Saturday evening’s victory means that the Boks won two and lost two times in their end of year tour of Europe.